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Fig. 2 | Genome Biology

Fig. 2

From: Ythdf2-mediated m6A mRNA clearance modulates neural development in mice

Fig. 2

Ythdf2 is required for normal embryonic cortical development. a Sagittal brain sections of E12.5 and E14.5 were stained with H&E. An enlarged view of the forebrain cortex is shown. Scale bar indicates 20 μm. b Thickness of the cortical layer in Ythdf2+/−, Ythdf2−/−, and their wild-type littermates at E12.5 and E14.5. Error bars represent mean ± standard deviation, n = 3 embryos and 3 technical replicates. c Immunostaining of E12.5 and E14.5 brain sagittal sections for Dcx in wild-type, Ythdf2+/−, and Ythdf2−/− littermates. Nuclei were counterstained with DAPI. VZ ventricular zone, SVZ subventricular zone, IZ intermediate zone, CP cortical plate. d Ratio of the thickness of Dcx-immunolabeled neuronal layers over cortical layers in Ythdf2+/− and Ythdf2−/− compared with wild type. Error bars represent mean ± standard deviation, n = 3 embryos and 3 technical replicates. *P < 0.05, **P < 0.01, ***P < 0.001, Student’s t-test

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