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Fig. 1 | Genome Biology

Fig. 1

From: Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome

Fig. 1

Discovery of negatively selected genes. Schematic workflow for using ICGC/TCGA data to detect negatively selected genes. a Workflow for calculating d N /d S using counts of somatic mutations and the human coding sequence without using a substitution model. b Descriptive values using mutational data to correct for mutation frequencies. The substitution model exemplified uses seven substitution types, but any other model could be implemented. The observed frequency of substitutions is used to correct for the expected number of sites in all transcripts to calculate a corrected value of d N /d S (SSB- d N /d S )

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