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Fig. 7 | Genome Biology

Fig. 7

From: The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex

Fig. 7

circPVT1 regulates its own expression binding the mut-p53/YAP/TEAD complex. a, b ChIP analysis of YAP and Pol II in the CAL27 cell line after the transfection of pcDNA3-circPVT1-a and pcDNA3. c–e DRB-4sU assay. c circPVT1 level was detected by RT-qPCR in pcDNA3-circPVT1-a and pcDNA3 transfected cells. d Nascent circPVT1 expression level was detected by RT-qPCR. e Nascent PVT1 expression level was detected by RT-qPCR. f The transcriptional mut-p53/YAP-circPVT1/TEAD complex bound to the circPVT1 promoter. Data are shown as mean of three replicates ± standard deviation (Student’s test; *p < 0.05; **p < 0.01; ***p < 0.001)

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Genome Biology

ISSN: 1474-760X

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