Table 1 The 38 lung-specific TFs in LungNet and their differential activity characteristics
LungNet TF | LSCC (RNA-seq) | LSCC (DNAm) | LCIS (mRNA) | LCIS (DNAm) | Smoking (DNAm) | Smokinga (mRNA-Affy) |
|---|---|---|---|---|---|---|
TFEC | –24.14 | 18.61 | 2.9 | 5.16 | –4.58 | UP |
TBX2 | –33.08 | –18.69 | –5.52 | –1.16 | –6.55 | DN |
FOXA2 | –22.01 | –17.57 | –1.43 | –7.91 | 1.41 | NA |
TAL1 | –40.65 | -18.45 | –2.28 | –0.87 | –5.33 | DN |
TBX4 | –44.91 | –7 | –1.68 | –4.45 | 1.61 | DN |
NKX2-1 | –34.8 | –2.76 | 1.73 | –2.63 | 5.18 | NA |
GATA2 | –40.81 | –11.36 | –2.47 | –1.53 | –5.26 | NA |
EPAS1 | –35.72 | –32.7 | –3.28 | –5.25 | –1.69 | DN |
FOXJ1 | –9.44 | –16.65 | –1.73 | –6.94 | –1.86 | NA |
LDB2 | –44.35 | –11.99 | –3.16 | 2.14 | –5.32 | DN |
ETS1 | –32.67 | –5.25 | 0.15 | –3.42 | –5.37 | NA |
ETV1 | –33.76 | –9.3 | –5.97 | 0.25 | –2.66 | NA |
ERG | –33.38 | –23.56 | –3.16 | –2.76 | –5.23 | DN |
ELF3 | 3.56 | 10.57 | 1.96 | –4.44 | 5.73 | NA |
SOX13 | –30.47 | 15.77 | –7.33 | –1.8 | 1.13 | NA |
AHR | –21.6 | –0.61 | –2.67 | –2.98 | 1.7 | NA |
PML | –9.33 | –7.3 | 2.82 | –1.56 | –2.06 | NA |
FOXA1 | –9.57 | 11.95 | –0.21 | –5.57 | 5.51 | NA |
MLLT4 | –1.28 | –12.25 | 2.53 | 2.16 | 1.52 | DN |
BGN | –9.85 | –24.23 | –4 | –6.12 | 3.08 | NA |
ZFP36 | –11.43 | –7.05 | 2.9 | 1.05 | 2.62 | NA |
TNXB | –27.31 | –12.72 | –4.44 | –3.58 | 4.19 | NA |
SOX18 | –39.37 | –13.51 | –3 | 1.23 | –4.88 | NA |
TEAD2 | –19.59 | –32.39 | –3.26 | –4.49 | –2.64 | NA |
XBP1 | 5.66 | –6.78 | –0.54 | 1.69 | –0.07 | NA |
MEOX2 | –40.54 | –3.58 | –4.73 | –1.6 | 1.28 | NA |
KLF4 | –14.85 | 2.89 | 4.05 | –0.33 | 5.44 | NA |
HIF3A | –36.97 | –9.37 | –5.85 | 3.44 | 3.65 | NA |
LSR | 9.53 | 4.06 | 2.51 | –4.1 | 5.27 | NA |
KLF9 | –29.79 | –21.26 | –5.49 | 1 | –5.1 | NA |
STON1 | –36.61 | –7.75 | –4.79 | –3.04 | 1.9 | NA |
PPARG | –25.61 | –19.38 | –0.45 | –4.53 | –5.77 | UP |
ZFP36L2 | –29.34 | –4.42 | –3.63 | 1.66 | –3.36 | NA |
CEBPD | –15.4 | –0.86 | –0.07 | –0.14 | –4.08 | NA |
TRIP10 | 0.09 | –5.79 | –3.52 | –1.22 | 3.94 | NA |
NR2F2 | –20.82 | –8.14 | –6.41 | –7.52 | 3.61 | NA |
TGFB1I1 | –15.65 | –25.46 | –4.86 | –4.96 | 1.52 | NA |
EHF | 6.17 | 25.89 | 2.3 | –3.08 | 5.98 | NA |