Fig. 4
From: The multidimensional mechanisms of long noncoding RNA function
Gene regulation linked to long noncoding RNA (lncRNA) transcription. a Airn transcription reduces the recruitment of RNAPII to the Igf2r promoter, a mechanism known as ‘transcriptional interference’, causing the silencing of the maternal Igf2r gene. Transcriptional overlap does not occur at the other imprinted genes in the Igf2r cluster—Slc22a2 and Slc22a3—where the silencing properties of Airn might reside in its RNA [97, 98]. b Cdkn1b expression is positively regulated by a cis-element of the genomic locus of Lockd, whereas the lncRNA is dispensable for this function [99]