Skip to main content
Fig. 1 | Genome Biology

Fig. 1

From: Promoting RNA editing by ADAR attraction

Fig. 1

Editing inducer elements (EIEs) regulate specific adenosine to inosine (A-to-I) editing. a Structural elements that contribute to selective and efficient editing around the edited adenosine (red star): short imperfect stem (gray background), internal loop and EIE identified in the study by Daniel et al. [1] (red background). The suggested model proposes ADAR (adenosine deaminase that acts on RNA) recruitment to the EIE, thereby increasing the local concentration in the vicinity of the edited RNA molecule. This improves the conditions for catalysis and promotes efficient editing at the specific site. b A high local concentration of ADARs may result in hyperediting of the long double-stranded RNA (orange stars). Because the hyperedited double-stranded RNA is less favorable for ADAR binding, the local concentration of ADARs decreases

Back to article page