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Fig. 3 | Genome Biology

Fig. 3

From: The influence of microRNAs and poly(A) tail length on endogenous mRNA–protein complexes

Fig. 3

DDX6-bound mRNAs have shorter poly(A) tails. a Comparison of mean poly(A)-tail lengths of DDX6-bound mRNA with those of total mRNA. Results are plotted for each gene with sufficient PAL-seq tags in both samples. b The differences in mean poly(A)-tail lengths observed between DDX6-bound and total mRNA for each gene plotted in a (white line, median; box, quartiles; whiskers, 1.5 interquartile range). c Relationship between the difference in mean tail lengths observed between the DDX6-bound and total mRNA with respect to the mean tail lengths of total mRNA. d Mean poly(A)-tail lengths in the total mRNA and in DDX6-bound RNA following the indicated transfections (line, median; box, quartiles; whiskers, 1.5 interquartile range). Significance of the differences was evaluated using the paired Mann–Whitney U test. e The modest effects of miRNAs on mean poly(A)-tail lengths of DDX6-bound mRNAs. Plotted are the changes in mean poly(A)tail lengths of DDX6-bound mRNAs when comparing samples with the indicated transfected and mock-transfected miRNAs, distinguishing the results for mRNAs that contain at least one site to the cognate miRNA (site, red) from those for mRNAs that do not (no site, black). Significance was evaluated using the two-tailed K–S test

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