Fig. 6

Mapping of AGO2 binding to the ERβ + and ERβ − cell genomes. a Heatmap showing the AGO2 binding sites detected in ERβ + (Ct-ERβ) and ERβ − (wild-type (wt)) MCF-7 cells; CTRL IgGs. The boxes to the right display, for each cluster generated, the mean read densities within and around the AGO2 binding sites. b Distribution of annotated AGO2 binding sites with respect to the nearest transcription start site in ERβ + and ERβ − cells. c The most enriched transcription factor binding motifs identified within the three binding clusters identified are reported, together with the frequency observed in each case (light–dark blue boxes) and the mRNA expression level of the indicated transcription factors (gray, undetected)