Skip to main content
Fig. 6 | Genome Biology

Fig. 6

From: McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes

Fig. 6

McEnhancer predictions are validated through enrichment of histone marks and overlap with Hi-C data. Enrichment of histone modification marks: a H3K27ac and b H3K4me1 for clusters with predicted mesodermal expression (red), compared to DHSs near these mesodermal genes but were not selected by McEnhancer (green), DHSs selected by McEnahncer but with no mesodermal activity (blue), and DHSs that were not slected to regulated any of the clusters (purple). c Validation of predicted DHS-gene pairs by overlapping with identified fragment-promoter Hi-C interactions. For each gene cluster, number of DHS-gene pairs which overlap with Hi-C fragments and for which these fragments were linked to the same genes was counted (blue bars). Percentages represented by this overlap with respect to filtered predicted DHS-gene pairs are shown by the orange line. Random refers to null expectation derived from data shuffling, see Methods

Back to article page