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Table 1 Editing values across 21 species

From: Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance

Organisma

Tissue/Source

Source readsb [% aligned]

Hyper-editing reads

Editing events

Unique editing sites [% A-to-G of all types]

Unique sites overlapping with coding regionsc [% of total]

Unique sites overlapping with repeatsc [% of total]

Human

Brain

64,313,204 [92]

22,117

117,383

75,984 [99]

31 [0]

70,160 [92]

Chimpanzee

Brain

20,083,064 [66]

2327

10,866

9916 [95]

76 [1]

9089 [92]

Rhesus

Brain

215,339,102 [87]

169,735

921,561

525,245 [91]

1796 [0]

499,388 [95]

Mouse

Brain

114,374,684 [90]

5784

28,910

13,748 [94]

99 [1]

9497 [69]

Rat

Brain

238,077,800 [84]

23,724

119,260

31,788 [87]

1096 [3]

23,562 [74]

Minke whale

Brain

51,470,260 [94]

20,301

180,079

121,897 [100]

701 [1]

106,429 [87]

Cow

Brain

208,706,410 [87]

70,520

389,830

200,770 [99]

1161 [1]

188,187 [94]

Sheep

Brain

31,846,364 [91]

15,792

83,756

17,316 [93]

84 [0]

15,198 [88]

Opossum

Brain

69,848,223 [65]

613

2926

2168 [90]

132 [6]

1786 [82]

Chicken

Brain

269,226,888 [88]

24,690

169,793

79,728 [98]

2991 [4]

42,718 [54]

Lizard

Brain

183,282,934 [60]

98,483

700,905

122,793 [98]

284 [0]

52,343 [43]

Frog

Brain

51,896,478 [75]

54,519

388,744

147,172 [97]

180 [0]

69,943 [48]

Elephant shark

Brain

139,569,606 [75]

67,704

449,965

200,171 [89]d

428 [0]

162,066 [81]

Purple sea urchin

Young juvenile

76,613,634 [71]

36,570

216,215

83,594 [80]d

239 [0]

25,661 [31]

Octopus

CNS

344,308,354 [86]

1,135,890

7,851,521

1,053,826 [99]

-

-

Sea hare (Aplysia)

CNS

63,075,904 [77]

2952

23,757

12,546 [95]

2 [0]

936 [7]

Fly (Drosophila)

Head

257,255,489 [97]

6124

57,065

39,472 [100]

1124 [3]

14,471 [37]

Nematode (C. elegans)

Larvae

133,158,570 [97]

8691

65,543

21,713 [100]

244 [1]

11,782 [54]

Coral

WT

65,782,768 [61]

47,546

314,345

127,069 [88]

-

-

Yeast (S. cerevisiae)

WT

23,339,332 [99]

7

42

12 [63]

-

-

Thale cress (Arabidopsis)

WT

49,166,984 [96]

5

26

11 [13]

-

-

  1. aAdditional details are given in the table in Additional file 2
  2. bAll samples were run as single-ended and strand-indifferent (for comparison reason)
  3. cWe annotated coding regions using xenoRefGene (RefSeq for Human and Frog) and repeats regions using RepeatMasker, both from the UCSC Genome Browser. Octopus and Coral were omitted from this analysis since their genomes and annotations are not available in the UCSC Genome Browser
  4. dA-to-C signal with sequencing error features was also identified in the sample; thus, for specificity calculations A-to-C sites were excluded