Skip to main content
Fig. 6 | Genome Biology

Fig. 6

From: Topological organization and dynamic regulation of human tRNA genes during macrophage differentiation

Fig. 6

Model of multi-level tRNA gene regulation during macrophage development. a DNA loops bring together distal tRNA genes, RNAPII-transcribed genes, and enhancers that are coordinately downregulated during macrophage differentiation. b tDNAs are locally organized into clusters and physical contact domains that share similar activity and differential expression patterns in THP-1 cells. c Dynamic tDNA transcription correlates with proximal motif occupancy for specific, putative regulatory factors, such as HIF1A and EGR1. Downregulation of tRNA genes coincides with enhanced promoter-proximal binding of MAF1, a negative effector of RNAPIII activity

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us