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Fig. 3 | Genome Biology

Fig. 3

From: DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A

Fig. 3

dCas9-SunTag-DNMT3A methylates the intragenic regions of KLF4 without affecting gene expression. a The percent of methylation across individual CpGs as determined using deep sequencing of amplicons in a 2.5-kb window of the KLF4 locus. The gray bar represents the guide RNA binding site. b The fold change relative to dCas9SunTag + scFvDNMT3A1 as measured by quantitative PCR for KLF4 expression

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