Fig. 1
From: Sparse conserved under-methylated CpGs are associated with high-order chromatin structure
Identification of scUMC. a Number of sample methylomes sharing either a given UMR (no less than four CpG, right) or a given UMC in an otherwise discarded UMR (less than four CpG, left). b Methylation levels of central UMC and flanking CpG sites in UMRs detected in B cells. c Methylation levels of scUMCs and flanking CpG sites detected in B cells. d Percentage of indicated epigenetic features (candidate UMCs or scUMCs) overlapping DHSs. Candidate UMCs represent all UMCs in discarded UMRs from the population of methylomes (n = 31). Further details are provided in “Methods” and Fig S2. e Average vertebrate PhastCons scores in 2.5-kb region flanking scUMCs or non-conserved UMCs (Chebyshev’s Inequality Probability < 0.95; see “Methods” for further details)