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Fig. 7 | Genome Biology

Fig. 7

From: A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes

Fig. 7

Possible modes of lncRNA emergence following coding potential loss. a A mutation could disrupt the functional protein production and be followed by additional mutations, further altering the sequence and the splicing pattern. b A genetic change can inactivate the promoter, which would lead to loss of mRNA production, and emergence of a new promoter, de novo or from a transposable element insertion, can yield a new gene that may re-use some of the remaining exons of the lost protein-coding gene. c A locus can be disrupted through genome rearrangements, juxtaposing the promoter of the lost protein-coding gene with new exonic sequences

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