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Fig. 4 | Genome Biology

Fig. 4

From: A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes

Fig. 4

Part of the sequence conservation in GLCP–lncRNA pairs can be explained by overlap with enhancer elements. a Genomic organization of the DPH5/S1PR1 locus in human and chicken. P values are from SSEARCH comparisons of the sequences of the syntenic loci. Gene model colors indicate the orientation of the gene. b Detailed characterization of three of the exons of XLOC_000933: transcription start sites mapped using CAGE by the FANTOM5 consortium [54]; RNA-seq coverage in the adipose tissue from the Human Proteome Atlas [55]; chromatin modifications characteristic of enhancers (H3K4me1), promoters (H3K4me3), and active regulatory elements (H3K27ac); DNAse I hypersensitivity clusters; and transcription factor (TF) binding sites identified using ChIP-seq by the ENCODE project taken from the UCSC genome browser; base-wise sequence conservation and multiple alignment of different vertebrates taken from the UCSC genome browser

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