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Fig. 2 | Genome Biology

Fig. 2

From: Non-base-contacting residues enable kaleidoscopic evolution of metazoan C2H2 zinc finger DNA binding

Fig. 2

Overview of sequence preferences of individual C2H2-ZF domains. a The heatmap shows the ratio of C2H2-ZFs with highest preference for each DNA triplet (y-axis) in each organism, relative to the count expected by chance (the expectation is calculated as the sum of counts in the column multiplied by the sum of counts in the row divided by the total sum of counts). Species tree (x-axis) is from the NCBI taxonomy database [27]. Y-axis is clustered. Fungi- and plant-specific DNA triplets are labeled. C2H2-ZF counts can be found in Additional file 1: Figure S2. b Number of triplets recognized by at least one C2H2-ZF in different organisms. Only C2H2-ZFs with matching predicted and experimental motifs are included, i.e. C2H2-ZFs whose base-contacting residues match at least one experimentally examined C2H2-ZF (by B1H [6, 16]) and whose recognition code-predicted motif matches the experimental motif (Pearson correlation > 0.9)

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