Fig. 1

a Summary of genomic profiling of CD4⁺ T cells during activation with anti-CD3/CD28 beads. We examined gene expression using microarray in activated and non-activated CD4⁺ T cells across 21 h and assayed cells in more detail at the 4-h time point using ChIP-seq, RNA-seq and PCHi-C. n gives the number of individuals† or pools* assayed. b Eight modules of co-regulated genes were identified and eigengenes are plotted for each individual (solid lines = activated, dashed lines = non-activated), with heavy lines showing the average eigengene across individuals. We characterised these modules by gene set enrichment analysis within the MSigDB HALLMARK gene sets; where significant gene sets were found, up to three shown per module. n is the number of genes in each module