Fig. 4

Dosage-response curves for the genes identified using Robust-ProGENI which showed significant change compared to control for a cisplatin, b docetaxel, and c doxorobicin in BT549 and MDA-MB-231 cell lines. Results are representative of at least three independent experiments and data expressed as mean ± standard deviation (SD), n = 3. P values are calculated using a two-tailed unpaired t-test. d The interaction network of genes highly ranked using Robust-ProGENI (green circles), genes highly ranked using Pearson correlation analysis (HPC; circles with red border), and the shared neighbors of these two groups (small grey circles with no borders). Edges correspond to experimentally obtained PPIs and genetic interactions extracted from the STRING database; only edges with high affinity scores (>500) are depicted. The degree of a gene that is highly ranked using ProGENI but not among the HPC genes (green circle with no border) shows the number of its HPC neighbors and the number of its shared neighbors with HPC genes. These figures were drawn using Cytoscape [90]