Fig. 5

Differentially abundant cell types present in human blood samples. a Relative abundance of specific T cell types with acute-fatal on the left of the heatmap and acute-survivor on the right as predicted by DCQ compared to convalescent survivors. Within the heatmap, darker blue represents a decrease in the abundance of a given cell type and darker red represents an increase in the abundance of a given cell type. The colour bar on the left is showing if the given cell type is significantly differentially abundant (greater than or less than 0 with a p value < 0.05) in acute-survivors only (green), acute-fatal only (red) or both (blue). b Similar heatmap for dendritic cell types and (c) is for natural killer cell types. Loss of circulating monocytes characterises fatal EVD. d Box and whisker plots depicting frequencies of peripheral blood monocytes in fatal EVD patients (black), EVD survivors (blue), malaria patients (brown) and other febrile patients (green) as shown by FACS. Horizontal bars represent median values and the edge of the boxes represent 10–90 percentiles. Statistical analysis was performed via non-parametric Kruskal–Wallis test followed by Dunn’s post-test. ns non-significant, *p ≤ 0.05. e Correlation analysis indicating positive correlation between frequency of CD14+ monocytes and the Ct values. Non-parametric Spearman’s rank correlation analysis was performed. The line indicates a linear regression