Fig. 6
From: Identifying aggressive prostate cancer foci using a DNA methylation classifier
Clinical information for predicted TCGA groups. a Pre-operative PSA among the aggressive (n = 215) and non-aggressive (n = 64) groups. Welch two sample t-test = 0.005. Tumor size represented by the average intermediate dimension in centimeters among the aggressive (n = 87) and non-aggressive (n = 25) groups. Welch two sample t-test = 0.9428. Percentage of patients with lymph node metastases at the time of surgery among the aggressive (n = 187) and non-aggressive (n = 52) groups. Fisher’s exact two-tailed p(Yes) = 9.2 × 10−5. Pathological T stage distribution among the aggressive (n = 217) and non-aggressive (n = 64) groups. Fisher’s exact two-tailed p: p(T2) = 2.2 × 10−7, p(T3) = 7.7 × 10−7, p(T4) = 0.6969. GS distribution among the aggressive (n = 217) and non-aggressive (n = 64) groups. Fisher’s exact two-tailed p: p(GS 6) = 0.0591, p(GS 7) = 0.2539, p(GS 8–10) = 0.0220. P values <0.05 are marked by an asterisk. b Distribution of GS 3 + 4 and 4 + 3 tumors among the aggressive (n = 96) and non-aggressive (n = 34) groups. Fisher’s exact two-tailed p(3 + 4) = 0.8424. P values <0.05 are marked by an asterisk. Pathological T stage of GS 7 tumors among the aggressive (n = 96) and non-aggressive (n = 34) groups. Fisher’s exact two-tailed p: p(T2) = 1.5 × 10−4, p(T3) = 1.2 × 10−4, p(T4) = 1