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Table 1 Characteristics of the discovery (n = 8863) and replication (n = 4111) studies

From: DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Study

n

Country

Age (years)

Women (%)

CRP (mg/L)

BMI (kg/m2)

Discovery (European)

 CHS

187

USA

76 (5)

56

6.6 (11.0)

31 (6)

 EPIC-Norfolk

1287

UK

60 (9)

54

3.3 (5.4)

27 (4)

 FHS

2427

USA

66 (9)

52

3.1 (6.7)

28 (5)

 InCHIANTI

498

Italy

63 (16)

55

3.2 (3.5)

27 (4)

 KORA

1700

Germany

61 (9)

51

2.3 (3.7)

28 (5)

 LBC 1921

169

UK

87 (0)

54

3.7 (8.4)

26 (4)

 LBC 1936

296

UK

70 (1)

50

5.3 (6.8)

28 (4)

 NAS

648

USA

73 (7)

0

3.3 (6.1)

28 (4)

 Rotterdam

702

Netherlands

60 (8)

54

2.7 (4.7)

28 (5)

 WHI controls

471

USA

68 (6)

100

3.8 (5.5)

28 (6)

 WHI cases

478

USA

69 (6)

100

4.9 (6.4)

29 (6)

Replication (African American)

 ARIC

2264

USA

56 (6)

64

5.9 (7.8)

30 (6)

 CHS

193

USA

73 (5)

65

5.2 (5.6)

29 (5)

 GENOA

939

USA

66 (8)

71

6.7 (12.3)

31 (6)

 GTP

112

USA

41 (13)

70

5.9 (8.1)

33 (8)

 WHI controls

309

USA

62 (6)

100

6.1 (7.5)

31 (7)

 WHI cases

294

USA

64 (7)

100

7.2 (8.4)

32 (6)

  1. Characteristics are mean (SD), unless otherwise specified
  2. ARIC Atherosclerosis Risk in Communities, BMI body mass index, CHS Cardiovascular Health Study, CRP C-reactive protein, EPIC-Norfolk European Prospective Investigation into Cancer and Nutrition Norfolk, FHS Framingham Heart Study, GENOA Genetic Epidemiology Network of Arteriopathy, InCHIANTI Invecchiare in Chianti, KORA Kooperative Gesundheitsforschung in der Region Augsburg, LBC Lothian Birth Cohort, NAS Normative Aging Study, UK United Kingdom, USA United States of America, WHI Women’s Health Initiative