Fig. 4

IL10RA is a novel IBD candidate gene. a The 4C signal from the rs630923 locus in lymphocytes; signal on the y-axis is depicted as the percentage of fragends covered per pixel. Black bars indicate significant 4C signal (p < 10^–8); all coding genes located in this region are shown. The TSS of IL10RA co-localizes with a distant significant signal (~1 Mb from the viewpoint). Rs630923 and IL10RA localize to different haploblocks, meaning these regions do not co-segregate. b A network that consists of members of the IL10 signaling pathway. Red dots represent novel IBD candidate genes, orange dots represent candidate genes that were identified by 4C-seq as well as by GWAS, blue dots represent previously reported candidate genes that were not identified in the 4C-seq dataset, and black dots represent members of the IL10 pathway that have not been associated to IBD. Although many genes of the IL10 signaling pathway have been reported previously, we complement the network with three novel candidate genes including IL10RA