Fig. 5

pcgtAge/epiTOC is aggravated in pre-cancerous lesions whereas Horvath’s age-acceleration measure is not. a Left panel: the pcgtAge between normal lung tissue (N), lung carcinoma in situ (LCIS), and LCIS samples from patients who later progressed to an invasive lung cancer (LCIS- > LC). P values between respective groups are from a one-tailed Wilcoxon rank sum test. P value from a linear regression of pcgtAge versus group adjusted for age is also given at the top. Right panel: corresponding receiver operating characteristic (ROC) for discriminating the normal and all LCIS samples. AUC and 95 % CI is given. b Horvath’s age-acceleration measure between normal lung tissue (N), lung carcinoma in situ (LCIS), and LCIS samples from patients who later progressed to an invasive lung cancer (LCIS- > LC). P values between respective groups are from a one-tailed Wilcoxon rank sum test. c, d Exactly as a, b but now in a different Illumina 450 k data set, encompassing normal breast tissue, ductal carcinoma in situ (DCIS), and DCIS samples from women who later developed an invasive breast cancer (BC). e, f Exactly as a, b but now in an Illumina 450 k set which profiled normal breast tissue from healthy women (N), normal breast tissue adjacent to a breast cancer (NADJ), and breast cancers (BC). The number of samples in each group is given below