Fig. 4
From: CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types
Using CellMapper to prioritize GWAS disease genes. a The genetic locus surrounding sentinel SNP rs381144, associated with erythrocyte (Ery) and platelet (MkP) cell number. Other relevant SNPs in the region are shown. All genes predicted for expression in erythrocytes and platelets are displayed in red. b TRIM58 expression in primary mouse hematopoietic cells by qRT-PCR. MPP multi-potent progenitor, PreMegE pre-megakaryocyte-erythrocyte, Ery erythrocyte, MkP megakaryocyte/platelet, GMP granulocyte-monocyte progenitor, Neu neutrophil, MΦ macrophage, cDC conventional dendritic cell, B B cell, T T cell, NK natural killer cell. c The genetic locus surrounding sentinel SNP rs7554522, associated with inflammatory bowel disease (IBD). Genes colored in purple are predicted for simple epithelial cells, genes colored in green are predicted for T and NK cells. d C1orf106 and KIF21B expression in human primary cells and cell lines. Mono monocyte, HMEC1 endothelial cell line, Caco2 colon epithelial cell line, Organoid primary epithelial organoid from small intestine biopsy. All bars are mean +/− SD (n = 3–7 independent biological replicates) and letters indicate statistically significant differences between groups (p ≤0.05, Tukey’s honest significant difference test)