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Fig. 1 | Genome Biology

Fig. 1

From: Cancer biomarker discovery is improved by accounting for variability in general levels of drug sensitivity in pre-clinical models

Fig. 1

General levels of drug sensitivity can be estimated in a very large set of cell lines. a Heatmap showing pairwise correlations between IC50 values of all drugs in CGP. Drugs are arranged (by Euclidean distance) on the x-axis. A full heatmap with visible drug names and drug class labels is provided in Additional file 2: Figure S1. b Histogram of P values for pairwise correlation between all 138 drugs in CGP. c Scatterplot of imputed against measured IC50 values from eight-fold cross-validation in CGP. Imputed values were estimated using our iterative matrix completion algorithm. d P values of the Spearman correlation of the IC50 values of 38 randomly chosen drugs against the first principle component of the IC50 values of the remaining 100 drugs in CGP. Values above the dashed red line have P < 0.05

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