Fig. 11
From: An expanded evaluation of protein function prediction methods shows an improvement in accuracy
Case study on the human ADAM-TS12 gene. Biological process terms associated with ADAM-TS12 gene in the union of the three databases by September 2014. The entire functional annotation of ADAM-TS12 consists of 89 terms, 28 of which are shown. Twelve terms, marked in green, are leaf terms. This directed acyclic graph was treated as ground truth in the CAFA2 assessment. Solid black lines provide direct “is a” or “part of” relationships between terms, while gray lines mark indirect relationships (that is, some terms were not drawn in this picture). Predicted terms of the top-five methods and two baseline methods were picked at their optimal F max threshold. Over-predicted terms are not shown