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Fig. 5 | Genome Biology

Fig. 5

From: Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability

Fig. 5

H4K20me3 genic enrichment in senescent cells occurs at lowly expressed and unexpressed genes. a Mean H4K20me3 enrichment (read count) normalized to histone H4 in proliferating (PRO) cells across the gene body (transcription start site to transcription end site) of all non-repeat class coding genes divided into quartiles on the basis of expression level (Q1 = highest expression, Q4 = lowest expression, UN = unexpressed (FPKM = 0)). b As in a but evaluating H4K20me3 enrichment in control (CON) cells. c As in a but evaluating H4K20me3 enrichment in RS cells. d As in a but evaluating H4K20me3 enrichment in OIS cells. e Scatter plot according to the R function “densCols” comparing H4K20me3 ChIP enrichment difference (RS-PRO) at gene bodies normalized to histone H4 and expression level (FPKM) for all genes in PRO cells (control for RS cells). Colors are determined by the density of data points at each point of the chart, moving from low density (blue) to high density (red). f As in e but comparing H4K20me3 ChIP enrichment difference (OIS-CON) and expression level (FPKM) for all genes in CON cells (control for OIS cells)

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