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Fig. 4 | Genome Biology

Fig. 4

From: Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability

Fig. 4

H4K20me3 is frequently enriched at ZNF and repeat class genes in senescent cells. a Observed overlap/expected overlap (fold log2; enrichment compared with random) between base pairs in RS and OIS H4K20me3 DiffBind peaks, RS H4K16ac DiffBind peaks, DNA hypermethylated in RS regions, and DNA hypomethylated in RS regions and base pairs covered by specified genomic features. b Observed overlap/expected overlap (fold log2; enrichment compared with random) of RS H4K20me3 DiffBind peaks (in base pairs) and transposable elements (TEs). The x-axis shows TE evolutionary order ranked from most ancient to most recent, as defined previously [62]. c As in b but using OIS H4K20me3 DiffBind peaks. d All coding genes ranked by RS and OIS H4K20me3 enrichment (read count) at gene body normalized to histone H4. e Gene families represented among the 500 gene bodies most highly enriched for H4K20me3 in RS cells. f As in c but for H4K20me3 in OIS cells. g Gene families represented among all genes in the genome. h UCSC Genome Browser view of histone H4 and H4K20me3 ChIP-seq reads aligned along a 500-kb segment of chromosome 19 in proliferating (PRO) and RS cells

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