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Table 1 Group summaries for the number of singleton non-synonymous candidate variants in OMIM disease-associated genes among IGM’s 5965 samples

From: Unequal representation of genetic variation across ancestry groups creates healthcare inequality in the application of precision medicine

Geographic ancestry / ethnic group

Number of individuals

Number of singletons using internal reference cohort (n = 5,965)

Number of singletons using internal and ExAC reference cohorts (n = 66,217)

Median

Mean

SD

Median

Mean

SD

European

5,094

15

15.2

5.0

6

6.6

3.0

African (African American)

505

29

29.7

8.3

9

9.9

4.8

Latino ethnicity

93

28

28.3

6.0

10

10.9

5.5

East Asian

61

51

50.2

9.1

12

12.3

4.2

South Asian

38

49.5

50.5

7.4

12

12.7

3.8

Unassigned

174

24

22.7

11.9

8

8.3

5.8

  1. Data reflect using only the internal reference cohort and then subsequently supplementing the IGM internal reference cohort with variant information from the ExAC reference cohort of 60,252 controls of convenience
  2. SD standard deviation