Fig. 5
From: Enhancers reside in a unique epigenetic environment during early zebrafish development
Hypo-enhancers are active in adult tissues. a, b The fraction of hypo-enhancers (a) and hyper-enhancers (b) overlapping with a H3K27ac peak at the indicated developmental stages and tissues. c Box plot displaying expression values (RPKM) of genes within 20 kb of a hypo-enhancer overlapping with H3K27ac in brain. Expression data were obtained from publicly available RNA-Seq data from different tissues and developmental stages (indicated on the x-axis. *p < 0.05, paired Wilcoxon test, brain compared to all other samples. d Heat maps of normalized H3K27ac signal over hypo-enhancers in two different tissues (Intestine and Brain) and at 4 hpf (Dome). The heat map was sorted on brain, split, and subsequently sorted on intestine, etc. Yellow dashed lines indicate sorting transitions