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Fig. 1 | Genome Biology

Fig. 1

From: Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome

Fig. 1

Global methylation and coverage of single-cell WGBS. a Genome wide 5mC levels and coverage in single fibroblasts (blue) and hepatocytes (red). From outside to inside, the first layer represents 5mC level, the second layer coverage at each CpG site. 5mC levels and coverage were averaged among cells from each group and estimated using 1-Mb non-overlapping sliding windows. b Global 5mC levels at CpG sites for single cells and bulk for the two cell types and two age groups. c Percentage of genomic 3-kb windows containing at least 5 CpG sites in single hepatocytes and fibroblasts. Virtually all qualified windows in the single cells were found to overlap with their bulk samples. Grey, fibroblasts; blue, young hepatocytes; red, old hepatocytes

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Genome Biology

ISSN: 1474-760X

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