Blood lipids influence DNA methylation in circulating cells

Table 4 Estimated effect of TG, LDL-C, and HDL-C levels on DNA methylation using an approach based on Egger regression to exclude pleiotropic effects, including P values for an estimate of net pleiotropic effects of the PS SNPs

		Chr	Position	Mean DNAm (%)	Estimate (%/SD)^a	P value	Pleiotropy P value
TG	cg00574958	11	68,607,623	12	−1.1 (-1.4, -0.7)	5.7 × 10⁻⁹	0.37
	cg17058475	11	68,607,738	14	−1.3 (-1.8, -0.8)	2.3 × 10⁻⁷	0.82
	cg11024682	17	17,730,095	26	0.9 (0.3, 1.5)	1.9 × 10⁻³	0.50
	cg27243685	21	43,642,367	83	0.7 (0.3, 1.1)	6.4 × 10⁻⁴	0.18
	cg06500161	21	43,656,588	60	1.4 (0.8, 2.0)	2.9 × 10⁻⁶	0.75
LDL-C	cg27168858	1	55,351,660	78	0.7 (0.1, 1.3)	3.1 × 10⁻²	0.36
HDL-C	cg27243685	21	43,642,367	83	0.3 (-0.9, 1.5)	0.62	0.79
	cg06500161	21	43,656,588	60	−0.1 (-1.8, 1.7)	0.93	0.15

^a Estimate is the percentage change in DNA methylation per standard deviation change in lipid levels
DNAm DNA methylation

ISSN: 1474-760X