Fig. 3

Prognostic significance of candidate metabolic drivers. a Distribution of concordance indices in held-out validation set/s using 1000 prognostic classifiers for each cancer type (see the “Survival analysis” section in the “Methods” ). The dashed grey line (concordance index = 0.5) represents a model with no prognostic ability. For breast cancer, models were trained using half of the TCGA cohort and tested on the other half as well as independently tested on the Metabric cohort. b Percentage inclusion of the most frequently chosen genes in each cancer type (>20 % of models) following univariate and LASSO feature selection performed on the training cohort. Red asterisks indicate genes present in the core metabolic signature