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Fig. 2 | Genome Biology

Fig. 2

From: Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia

Fig. 2

Metabolic compartmental enrichment and candidate drivers of tumourigenesis. a Overlap of genes between the core candidate metabolic drivers (yellow) and three lists (blue, purple and green) of previously reported cancer drivers [1719]. The number in white (71) indicates overlap between the previously reported cancer drivers. b Pan-cancer null distributions of Spearman’s correlation coefficients between mRNA profiles of one million random (matched across tumour types) gene pairs. c, d Pan-cancer enrichment analysis of previously reported cancer-specific drivers (c) and the global (combined) list of candidate cancer drivers (d). The numbers in the cells indicate the total number of drivers correlated or anti-correlated with the corresponding metabolic gene (rows). The cutoffs for correlation were derived from the null distribution (95th and 5th percentiles) as shown in Fig. 2b. The cell colour indicates the probability values of expecting the observed correlation by random chance alone, with high intensities suggesting higher enrichment of previously reported cancer drivers in genes correlated with the candidate metabolic drivers. Tumour types (columns) were grouped by hierarchical clustering. The gene-wise (rows) clustering groups for the merged list of cancer drivers (d) are highlighted in orange (high correlation group) and blue (low correlation group). e, f Density plots of Spearman’s correlation coefficients of candidate metabolic drivers exhibiting significant correlation with the cancer-specific (e) and global list of previously reported cancer drivers (f). BLCA bladder urothelial carcinoma, BRCA breast invasive carcinoma, COADREAD colorectal adenocarcinoma, GBM glioblastoma multiforme, HNSC head and neck squamous cell carcinoma, KIRC kidney renal clear cell carcinoma, LUAD lung adenocarcinoma, LUSC lung squamous cell carcinoma, OV Ovarian serous cystadenocarcinoma, UCEC uterine corpus endometrial carcinoma

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