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Fig. 1 | Genome Biology

Fig. 1

From: Widespread parainflammation in human cancer

Fig. 1

The parainflammation signature. a An inflammatory response gene set was generated by combining genes that are found in at least two of three manually curated databases: the Ingenuity inflammatory response gene list, InnateDB innate immunity genes, and the Immunogenetic Related Information Source (IRIS). b Differential expression analysis of CKIα-deficient and CKIα-p53-deficient mice against wild type (WT) revealed 59 and 92 upregulated inflammatory response genes in the single and double knock outs (K/O), respectively, and 40 genes upregulated in both. The 40 genes were designated as the parainflammation (PI) gene signature. The heatmap shows the expression levels of the 111 upregulated genes (red, high expression; blue, low expression). c Upstream regulatory analysis revealed a strong enrichment for genes regulated by lipopolysaccharide and immune pathways that are activated by it. The rows show the top enriched, non-chemical regulators, the columns are the 40 PI genes, and a blue cell represents regulation

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