Fig. 4

Results of the application of OncodriveFML to identify driver splice intronic regions and 3′ UTRs. The results of OncodriveFML are illustrated on mutations found across the pan-cancer cohort of the WG-505 dataset. a, d QQ plots comparing the expected and observed distribution of FM bias p values of splice intronic regions and 3′ UTRs mutated in the pan-cancer cohort. b, c, f–h Mutation needle-plots of selected splice intronic regions and 3′ UTRs. e Significance of the 3′ UTR of the CHAF1B gene across several cohorts of both the WG-505 and WG-608 datasets