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Fig. 2 | Genome Biology

Fig. 2

From: High type I error and misrepresentations in search for transgenerational epigenetic inheritance: response to Guerrero-Bosagna

Fig. 2

Interpretation of our data explained. Level four comparisons are depicted from Table three of [1], showing zero numbers in two critical intersections. When interpreting our data, we considered a methylation change between experimental and control samples to be true transgenerational epigenetic inheritance (TGEI) if we found it as a common hit in four comparisons involving G1R MGC, G1R sperm, G2R MGC, and G2R sperm. Finding zero hits in the intersection of four comparisons was interpreted as lack of evidence for TGEI. For example, finding a common hit between G1R MGC and G1R sperm but not in G2R samples meant that the aberration was erased in G2. Similarly, finding it in G2R but not in G1R samples meant that it did not originate from the G1 exposure. Finding it in G1R and G2R MGC but not in sperm samples meant that it could not be transmitted between generations by G1R sperm or G2R sperm. Note that level 2 and 3 analyses were shown as balloons but level four analyses were omitted from the commentary by Guerrero-Bosagna

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