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Fig. 1 | Genome Biology

Fig. 1

From: Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies

Fig. 1

Chromosomal instable T-ALL display recurring chromosome copy numbers, as assessed by array CGH. a Two representative T-ALLs analysed using array CGH, compared to a euploid reference, showing recurrent gains of chromosomes 4, 9, 14 and 15, and other tumour-specific alterations. The purple bars indicate the mean log-value of the respective chromosome. b Cumulative single-cell sequencing libraries to simulate bulk data, showing a comparable karyotype as found by aCGH. c Single-cell sequencing analysis of four representative cells from T-ALL 1, showing identical chromosome copy numbers to the aCGH profile (cell 1), or cell-unique copy numbers (cells 2, 3 and 4; red arrows)

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