Fig. 6

Common lipid signaling in the ovarian cancer microenvironment. a A transcriptome-derived model depicting the cellular origins and targets (tumor cells, TAMs) of phospholipid degrading enzymes, AA and LPA. b An analogous model for AA-derived eicosanoid mediators and the sources of enzymes involved in their synthesis. The models are based on the data in Fig. 5a and b. Genes in square brackets are expressed in tumor cells in small subset of patients (Table 1). The source of ligands is indicated as follows: red for tumor cells, blue for TAMs, and purple for both. Colored gene names indicate higher expression tumor cells (red) or TAMs (blue). Each receptor is represented by one or more identical symbols according to their expression levels (as in Fig. 4). [ ]: expressed in subset of patients. Red asterisks denote components associated with a poor clinical outcome (based on the data in Figs. 7–9). Gene names are explained in Additional file 3: Datasets S8 and S9