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Fig. 5 | Genome Biology

Fig. 5

From: Simultaneous profiling of transcriptome and DNA methylome from a single cell

Fig. 5

Profile of allelic-specific transcription and methylation. a Histogram of methylation levels for all CpG sites within a representative single cell. b Bar graph showing the proportion of mono-allellic or bi-allelic SNPs as measured by scRRBS. Each site with known strain-specific SNPs that overlapped with RRBS fragments were interrogated for their presence of C57BL/6 J and DBA/2 J SNPs. Sites that covered both SNPs were considered bi-allelic otherwise are considered mono-allelic. Each bar represents the distribution for a single cell. c Bar graph showing the distribution of methylation level within bi-allelic fragments. Each bar represents the distribution for a single cell. d Scatter plot of DBA/2 J-strain-specific Copa methylation and expression across single cells. Each point represents a single cell and the position on the graph shows the DBA/2 J specific methylation and expression levels for Copa

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