Fig. 5

Signatures present in esophageal carcinoma. a The signatures identified in a cohort of ESCA tumors by deconstructSigs, using the input reference signatures from [4]. The prevalence, defined as the fraction of patients the signature was detected in, is plotted for each mutational signature identified, and the proportion of patients with a higher fraction of early (red) or late (blue) mutations corresponding to that signature is shown. b, c A specific analysis of two esophageal adenocarcinomas exhibiting signs of signature 17 activity. The mutational profiles are given for all the mutations identified in both tumors, as well as the mutations classified as early or late. Signature 17 was identified as the largest contributor to the early mutations of patient TCGA-2H-A9GR (b) whereas it was identified as the contributing to the generation of the majority of late mutations in patient TCGA-L5-A4OU (c)