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Fig. 4 | Genome Biology

Fig. 4

From: P16-specific DNA methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis

Fig. 4

Characterization of the P16-Dnmt binding fragments and methylation status of the promoter CpG islands in P16 and control genes in P16-dnmt stably transfected cells. a Chromatin-immunoprecipitation-sequencing (ChIP-Seq) and Illumina methylation 450 K array results in the ink4a locus in BGC823 cells; b DHPLC methylation analysis of CpG islands in P14 and ZNF382 promoters in GES-1 cells expressing P16-Dnmt. DNA samples with and without M.sssI methylation were used as methylated and unmethylated controls

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