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Table 1 Summary of all mice challenged with sporozoites

From: Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining

Parasite line

Sporozoite dose injected i.v.

Infected mice/total mice

Sporozoite-induced breakthrough parasites

WT

10,000

4/4

 

WT

10,000

4/4

 

WT

10,000

4/4

 

SpZFN

10,000

0/4

 

SpZFN

25,000

1/10

SpZFN SI 1

SpZFN

25,000

3/9

SPZFN SI 2–4

SpZFN

500,000

4/4

SpZFN SI 5–8

SpZFN

25,000

3/16

SpZFN SI 9–11

LsZFN

10,000

4/4

LsZFN SI 1–4

Sp2ZFN

25,000

0/4

 

Sp2ZFN

10,000

0/4

 

Ls2ZFN

25,000

5/12

Ls2ZFN SI 1–5

Ls2ZFN

250,000

4/8

LsZFN SI 6–9

Ls2ZFN

1,000,000

2/4

 

Uis4ZFN

25,000

0/8

 

Uis4ZFN

250,000

3/8

Uis4ZFN SI 1–3

TrapZFN

25,000

2/4

TrapZFN SI 1–2

TrapZFN

250,000

0/4

 

SpZFN SI 2

10,000

8/8

 
  1. SI sporozoite induced