Fig. 1
From: Host genetic architecture and the landscape of microbiome composition: humans weigh in
Apparent pleiotropy on mouse chromosome 10. An ideogram of the mouse chromosome 10 is shown with a 100–125 Mb region expanded to the right. The confidence intervals for different quantitative trait loci (QTLs) are indicated by colored solid lines. The QTLs affect both divergent microbial taxa (members of the bacterial families Coriobacteriaceae and Streptococcaceae) and complex diseases, including obesity (Obsty 3 (Obesity QTL3), Nhdlq4 (non-HDL QTL4) and Tgq21 (Triglyceride QTL21)), diabetes (Insq4 (Insulin sensitivity QTL4) and T2dm1sa (Type 2 diabetes mellitus 1)), and colonic tumor susceptibility (scc9). The position of genes associated with inflammation and innate immunity (IL22, IRAK3) and the two primary bacterial cell wall-degrading enzymes (LysP/M) are indicated on the far right by red bars