Fig. 8
From: Inferring regulatory element landscapes and transcription factor networks from cancer methylomes
Identification of in vivo TF networks, including upstream TFs and downstream enhancers and gene targets. The innermost black circle represents the 102,518 distal enhancer probes from the HM450 platform. The next level (labeled Hypo) shows the number of hypomethylated distal enhancer probes identified in each cancer type. The third level (labeled Paired hypo) shows the number of hypomethylated probes that were significantly linked to a putative target gene in each cancer type. The number in the outermost level corresponds to the number of putative target genes (each linked by expression level to a specific hypomethylated enhancer) predicted to be regulated by the indicated TF (fourth level); where multiple TF family members were identified, only the most strongly associated family member is listed