Domain atrophy creates rare cases of functional partial protein domains

Table 2 Cases of failure modes or false positives

Types of failure modes or false positives	Number of instances
Total	1,287
Gene prediction error	9
Containing nested domain	268
Multi-domain family	316
Small domain	173
Circular permutation	54
Short repeat	112
Disordered domain	85
Theoretical model	9
No other reference structure available	27
Complete structural domain	234

Domain instances with atrophy scores between 0.15 and 1 that were manually checked and classified into one of the failure modes or false positives.

ISSN: 1474-760X