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Figure 7 | Genome Biology

Figure 7

From: Domain atrophy creates rare cases of functional partial protein domains

Figure 7

Downstream domain-bounded atrophy: 2-hydroxyacid dehydrogenase, NAD-binding domain. 2-Hacid_dh_C domains from (A) Staphylococcus aureus PurK (PDB: 3ORQ) and (B) Lactobacillus jensenii D-lactate dehydrogenase (PDB: 4PRL) (C) Superposition of S. aureus and L. jensenii 2-Hacid_dh_C domains shows the atrophied region (orange, residues 225-298) at the C-terminus. The reverse Rossmann-fold binding motif, GXXGXG, is conserved in both 4PRL (light pink) and 3ORQ (magenta). Note that the catalytically important Histidine (grey) that interacts with the nicotinamide moiety of NAD (gold) at the C-terminus is absent in 3ORQ.

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