Figure 7

Functional enrichment analyses of disrupted pathways. xseq-predicted genes along with their neighbors in biological pathways showing altered expression were derived from the xseq analyses (see ‘Materials and methods’ and Additional file 2). Functional enrichment was performed with Enrichr [31] using the genes obtained from the cohort 1 (A,B) and cohort 2 (C,D) data sets and their intersection (E,F) (see Additional file 2). The enriched terms from KEGG (A,C,E) and WikiPathways (B,D,F) with the 20 lowest Bonferroni adjusted P values are shown. Only terms with a Bonferroni corrected P<0.05 are conserved (see Additional file 2 for the complete Enrichr results). Each node of the graphs represents an enriched pathway where the color of a node represents its Bonferroni corrected P value. An edge between two nodes indicates that the pathways share genes. The larger the width of the edge, the larger the number of shared genes. FDR, false discovery rate.