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Figure 2 | Genome Biology

Figure 2

From: Cis-regulatory somatic mutations and gene-expression alteration in B-cell lymphomas

Figure 2

Comparison of the mutation rates in the cis-regulatory and protein-coding spaces. Only SNVs from cohort 1 (A) and cohort 2 (B) have been considered (see Additional file 1: Figure S2 for indels). TFBS mutation rates (y-axis) and protein-coding mutation rates (x-axis) are plotted for all the samples in cohort 1 (A) and cohort 2 (B). Each triangle represents a sample and is color-coded depending on the tumor subtype as in Figure 1. Dashed gray lines represent the identity function (x=y). Blue lines represent the linear regressions computed from the samples in the two data sets. The equations corresponding to the linear regressions (y∼x) are written on top of the plots along with the computed r 2 statistical measures. Dark gray areas surrounding the blue lines provide the 95% confidence region. The same x- and y-axis scales have been used for both cohort 1 (A) and cohort 2 (B). DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; PMBCL, primary mediastinal large B-cell lymphoma; SNV, single nucleotide variant; TFBS, transcription factor binding site.

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