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Figure 4 | Genome Biology

Figure 4

From: Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin

Figure 4

Blocks identified in photoaged skin are more hypomethylated in squamous cell cancer (SCC). (A) Distribution of methylation values in 450k probes measuring CpGs within the identified age- and sun exposure-associated blocks. (B) Distribution of methylation values in 450k probes measuring CpGs outside of the identified age- and sun exposure-associated blocks. (C) Distribution of methylation values in 450k probes measuring CpGs within open sea regions and within the identified age- and sun exposure-associated blocks. (D) Distribution of methylation values in 450k probes measuring CpGs within open sea regions and outside the identified age- and sun exposure-associated blocks. (E) Heatmap showing mean methylation in blocks identified comparing O-exp and Y-pro epidermis. Samples and blocks are ordered by hierarchal clustering. Yellow/red indicate higher/lower methylation, respectively.

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